胶原靶向治疗增生性瘢痕蛋白药物的制备及应用

Preparation method and application of protein drug for collagen targeted therapy of hyperplastic scar

Abstract

本发明属基因工程领域,涉及靶向hIL-10的重组蛋白及其应用。本发明重组蛋白是由人白细胞介素10(humaninterlenkin10,hIL-10)与胶原特异结合的CBD多肽在基因水平融合后表达的重组蛋白,重组后形成了一种新的蛋白。该蛋白具有与hIL-10同样的抗病毒、抗肿瘤以及机体免疫功能的活性;更为重要的是CBD-IL-10在伤口愈合过程中能够与胶原特异靶向结合,作为治疗增生性瘢痕及瘢痕疙瘩疾病药物的应用中,可预防抑制瘢痕的形成。
The invention belongs to the field of gene engineering and relates to a targeted hIL-10 recombinant protein called as CBD-IL-10 for short and the application of the CBD-IL-10. The recombinant protein is a recombinant protein expressed by a CBD polypeptide combined by human interlenkin10, hIL-10 and collagen specificity after the fusion in a gene level, and a new protein is generated after recombination. The protein has the anti-virus and anti-tumor activities as well as the immune function same as the hIL-10; and more importantly, the CBD-IL-10 can be combined with the collagen specificity ina targeted way during the wound healing process and can prevent and inhibit the formation of scars in the application of the drug for treating the hyperplastic scar and keloid.

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